Concurrent Session 8: Stem Cells, Skin Appendages and Tissue Regeneration

Room E1 + E2

Date: Saturday 21 September 2019, 09.00-10.30
Room: E1+E2

Chairs: TBA


09.00-09.10 075 (Poster 577)
The atypical kinase C regulates epidermal adhesive junctions and the cytoskeleton essential for epidermal stratification
M Rübsam,1,2 F Tellkamp,1,2 H Nolte,2,3,5 M Rinschen,2,4 M Peskoller,1,2,3 M Krüger1,2,5 and CM Niessen1,2,3 1Department of Dermatology, University of Cologne, Cologne, Germany, 2CECAD, University of Cologne, Cologne, Germany, 3CMMC, University of Cologne, Cologne, Germany, 4Department of Internal Medicine II, University of Cologne, Cologne, Germany and 5Institute for Genetics, University of Cologne, Cologne, Germany
09.10-09.20 076 (Poster 588)
Skin fibroblast heterogeneity and plasticity are determined by the local niche
A Korosec, S Frech, A Forsthuber, K Lipp and BM Lichtenberger Skin & Endothelium Research Division (SERD), Department of Dermatology, Medical University of Vienna, Vienna, Austria
09.20-09.30 077 (Poster 574)
Murine sebaceous gland homeostasis requires intact cutaneous innervation in a hair cycledependent context

R Clayton,1,2 E Hinde,1 X Lim,2 R Paus1 and M van Steensel2 1Centre for Dermatology, University of Manchester, Manchester, United Kingdom and 2Skin Research Institute of Singapore, Agency for Science, Technology and Research, Singapore, Singapore
09.30-09.40 078 (Poster 579)
Single cell transcriptome and epigenome analyses in a murine model of dystrophic epidermolysis bullosa
T Shimbo,1 S Yamazaki,1,2 T Kitayama,1,2 Y Ouchi,1,2 R Yamamoto,1,2 E Takaki,1,2 L Bruckner- Tuderman,3 J Uitto,4 Y Kaneda1 and K Tamai1 1Osaka university, Suita, Japan, 2StemRIM, Ibaraki, Japan, 3Freiburg Institute for Advanced Studies School of Life Sciences, Freiburg, Germany and 4Jefferson University, Philadelphia, PA
09.40-09.50 079 (Poster 575)
Characterization of aged dermal stem cell phenotype: implications for skin homeostasis
L Yndriago,1 H Iribar,1 I Prieto,1 V Pérez,1 L Gardeazabal,1 A Maeva,2 A Strange,2 A Gutierrez,1 A Matheu1 and A Izeta1 1Biodonostia Health Research Institute, San Sebastián, Spain and 2UCL Eastman Dental Institute, London, United Kingdom
09.50-10.00 080 (Poster 570)
DNA dioxygenases Tet1/2/3 control cell differentiation in the hair follicle keratinocytes via modulating the activity of BMP signaling pathway
G Chen,1 Q Xu,3 M Fessing,2 A Mardaryev,2 A Sharov,1 G Xu3 and V Botchkarev1,2 1Dermatology, Boston University, Boston, MA, 2Centre for Skin Sciences, University of Bradford, Bradford, United Kingdom and 3Shanghai Institute Biological Sciences, Shanghai, China
10.00-10.10 081 (Poster 580)
Spontaneous replication stress in Hair Follicle Stem Cells leads to inflammation in Hidradenitis Suppurativa
C Orvain,1,2 Y Lin,3F Jean-Louis,1,2 B Hersant,4,5 N Ortonne,6 C Hotz,4,5 P Wolkenstein,4,5 P Pasero,3 Y Lévy1,2 and S Hue1,2 1Inserm U955-Equipe 16, Créteil, France, 2Vaccine Research Institute (VRI), Créteil, France, 3Institut de Génétique Humaine-CNRS, Montpellier, France, 4Plastic, Reconstructive and Aesthetic Surgery Department, Henri Mondor Hospital, Créteil, France, 5Dermatology Department, Henri Mondor Hospital, Créteil, France and 6Pathology Department, Henri Mondor Hospital, Créteil, France
10.10-10.20 082 (Poster 587)
The dual role of stem cell-specific Bcl-2 function for epidermal regeneration and cancer
A Geueke,1,2 F Küster,1,2 G Mantellato1,2 and C Niemann1,2 1Center for Molecular Medicine, University of Cologne, Cologne, Germany and 2Institute of Biochemistry II, University of Cologne, Cologne, Germany
10.20-10.30 083 (Poster 582)
Differentiation of human skin-derived precursors (SKPs) into functional sensory neurons

A Bataille,1,2 R Leschiera,1 N Le Goux,3 O Mignen,3 C Brun,4 T Oddos,4 L Misery1,2 and N Lebonvallet1 1Laboratory of Interactions Neurons Keratinocytes (EA4685), Brest, France, 2Department of Dermatology, University Hospital, BREST, France, 3University of Western Brittany, Inserm U1227, BREST, France and 4Johnson & Johnson Santé Beauté France, Val de Reuil, France