Concurrent Session 4: Genetics, Cell Based Therapy and Wound Healing

Amphitheatre B

Date: Thursday 19 September 2019, 14.40-16.10
Room: Amphitheatre B

Chairs: TBA

Program

14.40-14.50 039 (Poster 283)
Genome-wide association study in frontal fibrosing alopecia identifies 4 genomic loci and implicates auto-immunity and xenobiotic exposure in aetiopathogenesis
C Tziotzios,1 C Petridis,2 N Dand,2 J Saklatvala,2 V Pullabhatla,3 CM Stefanato,1 DA Fenton,1 MA Simpson2 and JA McGrath1 1St John’s Institute of Dermatology, King’s College London, London, United Kingdom, 2Department of Medical Genetics, King’s College London, London, United Kingdom and 3UK NIHR GSTFT/KCL Comprehensive Biomedical Research Centre, London, United Kingdom
14.50-15.00 040 (Poster 284)
Deciphering the pathogenesis of central centrifugal cicatricial alopecia
L Malki,1 O Sarig,1 MT Romano,2 MC Mechin,3 N Shomron,4 M Simon,3 A McMichael,5 N Dlova,6 RC Betz2 and E Sprecher1 1Dermatology, Tel-Aviv Sourasky medical center, Tel Aviv, Israel, 2Institute of Human Genetics, University of Bonn, Bonn, Germany, 3INSERM U1056, University of Toulouse III, Toulouse, France, 4Tel Aviv University, Tel Aviv, Israel, 5Wake Forest Baptist Medical Center, Winston-Salem, NC and 6University of KwaZulu– Natal, Durban, South Africa
15.00-15.10 041 (Poster 280)
Transcription termination modulates human epidermal proliferation and differentiation
X Chen,1 S Lloyd,1 J Kweon,1 G Gamalong1 and X Bao1,2 1Molecular Biosciences, Northwestern University, Evanston, IL and 2Dermatology, Northwestern University, Chicago, IL
, USA
15.10-15.20 042 (Poster 279)
Keratinocyte specific biallelic mutations in mevalonate pathway genes due to postzygotic second hits drive linear and disseminated superficial actinic porokeratosis
A Kubo,1 T Sasaki,2 H Suzuki,3 A Shiohama,1 S Aoki,1 T Kawai,4 K Nakabayashi,4 K Hata,4 K Kosaki3 and M Amagai1 1Dermatology, Keio Univ, Tokyo, Japan, 2Center for Supercentenarian Medical Research, Keio Univ, Tokyo, Japan, 3Center for Medical Genetics, Keio Univ, Tokyo, Japan and 4National Center for Child Health and Development, Tokyo, Japan
15.20-15.30 043 (Poster 625)
Fibroblast-specific overexpression of collagen XII leads to a delay in skin repair
K Schönborn,1 S Willenborg,2 J Schulz,2 F Quondamatteo,3 S Eming,2 A Niehoff,4 T Imhoff,5 M Koch,5 T Krieg1 and B Eckes1 1Translational Matrix Biology, University of Cologne, Köln, Germany, 2Dermatology, University of Cologne, Cologne, Germany, 3Anatomy, University of Glasgow, Glasgow, United Kingdom, 4Biomechanics, University of Cologne, Cologne, Germany and 5Oral Musculoskeletal Biology, University of Cologne, Cologne, Germany
15.30-15.40 044 (Poster 623)
Changing endothelial cell fate in wound healing through modulation of Sox9 to reduce scarring
J Patel, H Hamilton, S Kahler, S Sim, H Wong and K Khosrotehrani Diamantina Institute, University of Queensland, Brisbane, QLD, Australia
15.40-15.50 045 (Poster 624)
Myeloid cell-specific Fli1 knockout mice exhibit systemic sclerosis-like vasculopathy and delayed wound healing due to impaired vasculogenesis
Y Fukui, T Miyagawa, M Hirabayashi, K Nakamura, J Omatsu, S Toyama, A Yoshizaki, S Sato and Y Asano Department of Dermatology, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Japan
15.50-16.00 046 (Poster 629)
The ATP-dependent chromatin remodeler BRG1 controls epidermal keratinocytes migration during human cutaneous wound healing
C Kellett,1 R Bhogal,2 N Botchkareva1 and M Fessing1 1Centre for Skin Sciences, University of Bradford, Bradford, United Kingdom and 2Global Research and Development Centre, Unilever, Sharnbrook, United Kingdom
16.00-16.10  047 (Poster 578)
Immunometabolic imbalance fosters skin ageing
E Carrasco,1,2,3 G Soto-Heredero,1,2,3 E Blanco3,2 and M Mittelbrunn3,1 2 1 Molecular Biology, Faculty of Sciences, Universidad Autónoma de Madrid, Madrid, Spain, 2Cell Biology and Immunology, Centro de Biología Molecular Severo Ochoa (CSIC-UAM), Madrid, Spain and 3 Rare and Genetically Based Diseases, Instituto de Investigación Hospital 12 de Octubre, Madrid, Spain