Lecture Title: NETs in health and disease
Arturo Zychlinsky was appointed director of the Department of Cellular Microbiology at the Max Planck Institute for Infection Biology in 2001. He studied biology at the Instituto Politécnico Nacional, Mexico D. F., Mexico (1980 – 1985). In 1991, he received his Ph.D. in Immunology from the Rockefeller University, New York, USA. Afterwards, he spent two years as a postdoctoral fellow at the Institut Pasteur, Paris, France. From 1993 to 2001 he was professor at the Skirball Institute and Department of Microbiology at the New York University School of Medicine. He is a member of the European Molecular Biology Organization (EMBO), the German National Academy of Sciences Leopoldina, the American Society and Academy of Microbiology, and the European Academy of Microbiology. The Zychlinsky lab is the one that discovered NETs (Neutrophil Extracellular Traps) which are made of chromatin and specific neutrophil proteins Currently, the lab is working on the mechanisms of NET formation as well as the function of NET components, especially histones, in order to understand the function of chromatin in immunity.
Gasdermin D plays a vital role in the generation of neutrophil extracellular traps. Sollberger G, Choidas A, Burn GL, Habenberger P, Di Lucrezia R, Kordes S, Menninger S, Eickhoff J, Nussbaumer P, Klebl B, Krüger R, Herzig A, Zychlinsky A. Sci Immunol. 2018 Aug 24;3(26). pii: eaar6689. doi: 10.1126/sciimmunol.aar6689.
The role of neutrophil extracellular traps in rheumatic diseases. Apel F, Zychlinsky A, Kenny EF. Nat Rev Rheumatol. 2018 Aug;14(8):467-475. doi: 10.1038/s41584-018-0039-z. Review.
The bacterial pigment pyocyanin inhibits the NLRP3 inflammasome through intracellular reactive oxygen and nitrogen species. Virreira Winter S, Zychlinsky A. J Biol Chem. 2018 Mar 30;293(13):4893-4900. doi: 10.1074/jbc.RA117.001105. Epub 2018 Feb 6.
Neutrophil Extracellular Traps: The Biology of Chromatin Externalization. Sollberger G, Tilley DO, Zychlinsky A. Dev Cell. 2018 Mar 12;44(5):542-553. doi: 10.1016/j.devcel.2018.01.019. Review.
Copper Regulates the Canonical NLRP3 Inflammasome. Deigendesch N, Zychlinsky A, Meissner F. J Immunol. 2018 Mar 1;200(5):1607-1617. doi: 10.4049/jimmunol.1700712. Epub 2018 Jan 22.
Cell-Cycle Proteins Control Production of Neutrophil Extracellular Traps. Amulic B, Knackstedt SL, Abu Abed U, Deigendesch N, Harbort CJ, Caffrey BE, Brinkmann V, Heppner FL, Hinds PW, Zychlinsky A. Dev Cell. 2017 Nov 20;43(4):449-462.e5. doi: 10.1016/j.devcel.2017.10.013. Epub 2017 Nov 2.
Diverse stimuli engage different neutrophil extracellular trap pathways. Kenny EF, Herzig A, Krüger R, Muth A, Mondal S, Thompson PR, Brinkmann V, Bernuth HV, Zychlinsky A. Elife. 2017 Jun 2;6. pii: e24437. doi: 10.7554/eLife.24437.
Immunodetection of NETs in Paraffin-Embedded Tissue. Brinkmann V, Abu Abed U, Goosmann C, Zychlinsky A. Front Immunol. 2016 Nov 22;7:513. eCollection 2016.
Neutrophil Extracellular Trap Formation Is Independent of De Novo Gene Expression. Sollberger G, Amulic B, Zychlinsky A. PLoS One. 2016 Jun 16;11(6):e0157454. doi: 10.1371/journal.pone.0157454. eCollection 2016.
Neutrophil oxidative burst activates ATM to regulate cytokine production and apoptosis. Harbort CJ, Soeiro-Pereira PV, von Bernuth H, Kaindl AM, Costa-Carvalho BT, Condino-Neto A, Reichenbach J, Roesler J, Zychlinsky A, Amulic B. Blood. 2015 Dec 24;126(26):2842-51. doi: 10.1182/blood-2015-05-645424. Epub 2015 Oct 21.
A myeloperoxidase-containing complex regulates neutrophil elastase release and actin dynamics during NETosis. Metzler KD, Goosmann C, Lubojemska A, Zychlinsky A, Papayannopoulos V. Cell Rep. 2014 Aug 7;8(3):883-96. doi: 10.1016/j.celrep.2014.06.044. Epub 2014 Jul 24.