Lecture Title: Discovering and targeting cell subpopulations in zebrafish development and melanoma
Liz Patton is a Professor and MRC Programme Leader Scientist at the MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, UK. Liz received a BSc Honours degree from King’s College at Dalhousie University, and a PhD from the University of Toronto, working with Mike Tyers to discover how E3 ubiquitin ligases control cell division. Following this, Liz received a Human Frontier Science Programme Postdoctoral Fellowship to work with Len Zon at Harvard Medical School, where she developed a zebrafish BRAF model for melanoma. Her lab uses chemical genetic approaches in zebrafish to investigate gene-drug interactions in melanocyte development and in melanoma. Dr Patton is an Executive Editor at Disease Models and Mechanisms (Company of Biologists), and Pigment Cell and Melanoma Research (Wiley). Dr Patton was the founding President of the Zebrafish Disease Models Society (2013-2015) and currently serves as a Board member and Treasurer, and is an elected member of the Young Academy of Scotland at the Royal Society of Edinburgh, and Society for Melanoma Research Steering Committee. Dr. Patton’s research is funded by the Medical Research Council, the European Research Council, and a L’Oréal Paris USA–MRA Team Science Award for Women in Scientific Research.
Sarvi S, Crispin R, Lu Y, Zeng L, Hurley TD, Houston DR, von Kriegsheim A, Chen C, Mochly-Rosen D, Ranzani M, Mathers ME, Xu X, Xu W, Adams DJ, Carragher NO, Fujita M, Schuchter L, Unciti-Broceta A, Brunton VG, Patton EE. ALDH1 bio-activates nifuroxzide to eradicate ALDHHigh melanoma-initiating cells. Cell Chemical Biology, 2018 Dec 20;25(12):1456-1469.
Ngeow K, Friedrichsen H, Linxin L, Zheng Z, Lisle R, Picaud S, Knapp S, Filippakopoulos P, Knowles H, Steingrimsson E, Patton EE, Goding CR. BRAF/MAPK and GSK3b signalling signaling converge to control MITF nuclear export. Proc Natl Acad Sci U S A. 2018 Sep 11;115(37):E8668-E8677
Al-Olabi L, Polubothu S, Dowsett K, Andrews KA, Stadnik P, Joseph AP, Knox R, Pittman A, Clark G, Baird W, Bulstrode N, Glover M, Gordon K, Hargrave D, Huson SM, Jacques TS, James G, Kondolf H, Kangesu L, Keppler-Noreuil KM, Khan A, Lindhurst MJ, Lipson M, Mansour S, O’Hara J, Mahon C, Mosica A, Moss C, Murthy A, Ong J, Parker VE, Rivière JB, Sapp JC, Sebire NJ, Shah R, Sivakumar B, Thomas A, Virasami A, Waelchli R, Zeng Z, Biesecker LG, Barnacle A, Topf M, Semple RK, Patton EE, Kinsler VA. Mosaic RAS/MAPK variants cause sporadic vascular malformations which respond to targeted therapy. J Clin Invest. 2018 Apr 2;128(4):1496-1508. PMID:29461977
Lopez-Baez JC, Simpson DJ, LLeras Forero L, Zeng Z, Brunsdon H, Salzano A, Brombin A, Wyatt C, Rybski W, Huitema LFA, Dale RM, Kawakami K, Englert C, Chandra T, Schulte-Merker S, Hastie ND, Patton EE. Wilms Tumor 1b defines a wound-specific sheath cell subpopulation associated with notochord repair. Elife. 2018 Feb 6;7. pii: e30657. doi: 10.7554/eLife.30657.PMID:29405914
Scahill CM, Digby Z, Sealy IM, Wojciechowska S, White RJ, Collins JE, Stemple DL, Bartke T, Mathers ME, Patton EE, Busch-Nentwich EM. Loss of the chromatin modifier Kdm2aa causes BrafV600E-independent spontaneous melanoma in zebrafish. PLoS Genet. 2017 Aug 14;13(8):e1006959
Brunsdon H, Patton EE. Fishing for ancestry. Elife. 2018 Aug 2;7. pii: e39524
Soengas MS, Patton EE. Location, location, location: Spatio-temporal cues that define the cell of origin in melanoma. Cell Stem Cell. 2017 Nov 2;21(5):559-561
Jackson IJ, Patton EE. Cell signalling: Red alert about lipid’s role in skin cancer. Nature. 2017 Sep 6.