Tiago R. Matos

Tiago R. Matos

Amsterdam, The Netherlands

EADV Guest Lecture

Date: Saturday 21 September 2019, 11.45-12.15
Room: Amphitheatre A

Lecture Title: Skin Resident T Cells: implications for immune homeostasis and disease

Introduced by: Wolfgang Weninger

Tiago R Matos has a longstanding interest in cellular immunology, particularly the interaction of T cells between human tissues and its relation to human autoimmune and inflammatory disorders. His Ph.D. thesis (2019) entitled “Skin Resident T cells: Implications for immune homeostasis and disease” is mostly compromised of research conducted at Harvard Medical School, under the mentorship of Prof. Dr. Rachael A. Clark. He focused on characterizing resident memory T cells (TRM) in healthy human skin, identifying the blood T cells precursors that differentiate into TRM and studying their role as auto-reactive T cells in psoriasis and GvHD. Tiago has received numerous grants (Luso-American Foundation, American Skin Association, Astrazeteca-Portugal, Dana-Farber Cancer Institute Medical Oncology Grant program, National Psoriasis Foundation, René Touraine Foundation, European Association of Dermatology & Venerology Research Fellowship) and published original articles in prominent journals including Nature Immunology, Journal of Investigative Dermatology, Blood, Science Translational Medicine and Journal of Clinical Investigation. In 2016, Tiago moved to Amsterdam (Netherlands) under the mentorship of Prof. Dr. Menno A. de Rie, continuing to study tissue T cells and starting residency in Dermatology.

Selected Publications
Dijkgraaf FE, Matos TR, Hoogenboezem M, Toebes M, Vredevoogd DW, Mertz M, van den Broek B, Song JY, Teunissen MBM, Luiten RM, Beltman JB, Schumacher TN. Tissue patrol by resident memory CD8+ T cells in human skin. Nat Immunol. 2019 May 20

Willemsen M, Linkute R, Luiten RM, Matos TR. Skin-resident memory T cells as a potential new therapeutic target in vitiligo and melanoma. Pigment Cell Melanoma Res. 2019.

Groth C*, van Groningen LFJ*, Matos TR, Bremmers ME, Preijers FWMB, Dolstra H, Reicherts C, Schaap NPM, van Hooren EHG, IntHout J, Masereeuw R, Netea MG, Levine JE, Morales G, Ferrara JL, Blijlevens NMA, van Oosterhout YVJM, Stelljes M, van der Velden WJFM. Phase I/II Trial of a Combination of Anti-CD3/CD7 Immunotoxins for Steroid-Refractory Acute Graft-versus-Host Disease. Biol Blood Marrow Transplant. 2019 Apr;25(4):712-719.

Gehad A, Teague JE, Matos TR, Huang V, Yang C, Watanabe R, O’Malley JT, Trimble CL, Kupper TS, Clark RA. A primary role for human central memory cells in tissue immunosurveillance. Blood Adv. 2018 Feb 13;2(3):292-298.

Matos TR, O’Malley JT, Lowry EL, Hamm D, Kirsch IR, Robins HS, Kupper TS, Krueger JG, Clark RA. Disease-specific IL-17-producing αb T-cell clones in clinically resolved psoriasis. J Clin Invest. 2017 Nov 1;127(11):4031-4041.

Matos TR. The Challenge of Effective Communication among Scientists. J Invest Dermatol. 2017 Nov;137(11):e183-e184.

Matos TR, de Rie MA, Teunissen MB. RTMS: High-Throughput Sequencing of the T-Cell Receptor. J Invest Dermatol. 2017 Jun;137(6):e131ee138.

Koolen PG, Matos TR, Ibrahim AM, Sun J, Lee BT, Frankenthaler RA, Lin SJ. Recurrence Rates Over 20 Years in the Treatment of Malignant Melanoma: Immediate Versus Delayed Reconstruction. Plast Reconstr Surg Glob Open. 2017 Jul 12;5(7):e1378.

Matos TR, Hongye L, Ritz J. RTMS: Mass Cytometry Analysis Tools for Decrypting the Complexity of Biological Systems. J Invest Dermatol. 2017 May;137(5):e43–e51.

Matos TR, Hongye L, Ritz J. RTMS: Experimental Methodology for Single-Cell Mass Cytometry. J Invest Dermatol. 2017 Apr;137(4):e31-e38.

Matos TR, de Rie MA. Discovery of skin lymphocytes was a game changer in experimental dermatology. Exp Dermatol. 2017 Aug;26(8):683-684.

Hirakawa M, Matos T, Liu H, Koreth J, Kim HT, Paul N, Murase K, Whangbo J, Alho AC, Nikiforow S, Cutler C, Ho VT, Armand P, Alyea EP, Antin JH, Blazar BR, Lacerda JF, Soiffer RJ, Ritz J. Low-dose interleukine-2 selectively activates discrete subsets of CD4 regulatory T cells and natural killer cells. JCI Insight. 2016 Nov 3;1(18):e89278.

Lampson BL, Kasar SK, Matos TR, Morgan EA, Rassenti L, Davids MS, Fisher DC, Freedman AS, Jacobson CA, Armand P, Abramson JS, Arnason JE, Kipps TJ, Fein J, Fernandes S, Hanna J, Ritz J, Kim HT, Brown JR. Idelalisib Given Front-line for Treatment of Chronic Lymphocytic Leukemia Causes Frequent Immune-Mediated Hepatotoxicity. Blood. 2016. 128(2), 195-203.

Alho AC, Kim HT, Chammas MJ, Reynolds CG, Matos TR, Forcade E, Whangbo J, Nikiforow S, Cutler CS, Koreth J, Ho VT, Armand P, Antin JH, Alyea EP, Lacerda JF, Soiffer RJ, Ritz J. Unbalanced recovery of regulatory and effector T cells after allogeneic stem cell transplantation contributes to chronic GVHD. Blood. 2016 4;127(5):646-57.

Matos TR, Sheth V. The symbiosis of phototherapy and photoimmunology. Clin Dermatol. 2016 Sep-Oct;34(5):538-47.

Matos TR, Ling TC, Sheth V. Ultraviolet B radiation therapy for psoriasis: Pursuing the optimal regime. Clin Dermatol. 2016 Sep-Oct;34(5):587-93

Matos TR, Sheth V. Novel applications of Phototherapy. Clin Dermatol. 2016 Sep-Oct;34(5):529-31.

Coelho MMV, Matos TR, Apetato M. The dark side of the light: mechanisms of photocarcinogenesis. Clin Dermatol. 2016 Sep-Oct;34(5):563-70.

Watanabe R, Gehad A, Yang C, Campbell L, Teague JE, Schlapbach C, Elco C, Huang V, Matos TR, Kupper TS, Clark RA. Human skin is protected by four functionally and phenotypically discrete populations of resident and recirculating memory T cells. Sci Trans Med, 2015 Mar 18;7(279):279ra39

EADV Guest Lecture: Tiago R. Matos

Amphitheatre A

Date: Saturday 21 September 2019, 11.45-12.15 Room: Amphitheatre A Lecture Title: Skin Resident T Cells: implications for immune homeostasis and disease Introduced by: Erwin Tschachler