PROGRAM
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Morning E2BRN | Chairs: Ellen van den Bogaard (Nijmegen, The Netherlands)+ Sara Brown (Edinburgh, UK) |
| Session 1: Interaction between skin and the environment |
09.00-09.30 | Keynote lecture Lipid metabolism and beyond in atopic dermatitis – including an introduction to a new COST action Sandrine Dubrac (Innsbruck, Austria) |
| Short communications |
09.30-09.45 | Application of skin organoid model to investigate gene-environment interaction in vitro Luke Johnston (Edinburgh, UK) |
09.45-10.00 | Topical DEHP exposure leads to inflammation and epidermal barrier damage in epidermal equivalents Deborah Minzaghi (Tirol, Austria) |
10.10-10.45 | Poster viewing + coffee/tea |
| Session 2: From epithelial cell differentiation to skin structure and function |
| Short communications |
10.45-11.00 | Multi-omics analysis identifies coordination and hierarchy of transcription factors controlling specific epithelial cell fates in corneal epithelium Jos Smits (Nijmegen, The Netherlands) |
11.00-11.15 | Investigating the PKCη-RIPK4 signaling axis in keratinocytes Lauren Herron (Ghent, Belgium) |
11.15-11.30 | Is the proteasome activity involved in filaggrin breakdown? Julie Briot (Paris, France) |
11.30-11.45 | Down-regulation of the NOTCH pathway during skin aging contributes to functional epidermal defects through miR-30a activation Jerome Lamartine (Lyon, France) |
11.45-12.00 | The Fate of Epidermal Tight Junctions in the stratum corneum: Their Involvement in the Regulation of Desquamation and Phenotypic Expression of Certain Skin Conditions Marek Haftek (Lyon, France) |
12.00-12.15 | The molecular arrangement of stratum corneum lipids: the role of ceramide NP and ceramide NS Andreea Nadaban (Leiden, The Netherlands) |
12.15-13.15 | Lunch and poster viewing |
Afternoon E2BRN | Chairs: Patrick Zeeuwen (Nijmegen, The Netherlands) + Yves Poumay (Namur, Belgium) |
| Session 3: Skin microbiota orchestrate epidermal function |
13.15-13.45 | Keynote lecture Skin microbiota regulation of barrier integrity and repair Elizabeth Grice (UPenn, USA) |
| Short communications |
13.45-14.00 | Antimicrobial late cornified envelope (LCE) proteins: the psoriasis risk factor LCE3B/C-del affects microbiota composition Hanna Niehues (Nijmegen, The Netherlands) |
14.00-14.15 | Segregation of filaggrin into small extracellular vesicles secreted by keratinocytes as a barrier homeostatic mechanism hijacked by Staphylococcus aureus Danuta Gutowska-Owsiak (Gdansk, Poland) |
14.15-15.15 | Poster viewing + coffee/tea
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| Session 4: Epidermal function in skin diseases |
| Short communications |
15.15-15.30 | Untangling the complex cytokine milieu in psoriasis and atopic dermatitis through organotypic epidermal models Luca Meesters (Nijmegen, The Netherlands) |
15.30-15.45 | Aryl hydrocarbon receptor ligand leflunomide exerts triple action to dampen the inflammatory skin disease atopic dermatitis Felicitas Pardow (Nijmegen, The Netherlands) |
15.45-16.00 | Experimental approaches for testing the pathogenicity of variants of uncertain signification to reduce diagnosis deadlocks in ichthyoses Nuria Pell-Vidal (Paris, France) |
16.00-16.15 | CD44 functions as a novel interacting partner of Aquaporin 5 in keratinocytes Laura Ramos Del Caño (London, UK) |
16.15-16.30 | Meeting closure, announcement of presentation prizes, departure for drinks
Ellen van den Bogaard + Sara Brown |