PROGRAM

Morning E2BRN

Chairs: Ellen van den Bogaard (Nijmegen, The Netherlands)+ Sara Brown (Edinburgh, UK)

Session 1: Interaction between skin and the environment

09.00-09.30

Keynote lecture

Lipid metabolism and beyond in atopic dermatitis – including an introduction to a new COST action

Sandrine Dubrac (Innsbruck, Austria)

Short communications 

09.30-09.45

Application of skin organoid model to investigate gene-environment interaction in vitro

Luke Johnston (Edinburgh, UK)

09.45-10.00

Topical DEHP exposure leads to inflammation and epidermal barrier damage in epidermal equivalents

Deborah Minzaghi (Tirol, Austria)

10.10-10.45

Poster viewing + coffee/tea

Session 2: From epithelial cell differentiation to skin structure and function

Short communications

10.45-11.00

Multi-omics analysis identifies coordination and hierarchy of transcription factors controlling specific epithelial cell fates in corneal epithelium

Jos Smits (Nijmegen, The Netherlands)

11.00-11.15

Investigating the PKCη-RIPK4 signaling axis in keratinocytes

Lauren Herron (Ghent, Belgium)

11.15-11.30

Is the proteasome activity involved in filaggrin breakdown?

Julie Briot (Paris, France)

11.30-11.45

Down-regulation of the NOTCH pathway during skin aging contributes to functional epidermal defects through miR-30a activation

Jerome Lamartine (Lyon, France)

11.45-12.00

The Fate of Epidermal Tight Junctions in the stratum corneum: Their Involvement in the Regulation of Desquamation and Phenotypic Expression of Certain Skin Conditions

Marek Haftek (Lyon, France)

12.00-12.15

The molecular arrangement of stratum corneum lipids: the role of ceramide NP and ceramide NS

Andreea Nadaban (Leiden, The Netherlands)

12.15-13.15

Lunch and poster viewing

Afternoon E2BRN

Chairs: Patrick Zeeuwen (Nijmegen, The Netherlands) + Yves Poumay (Namur, Belgium)

Session 3: Skin microbiota orchestrate epidermal function

13.15-13.45

Keynote lecture

Skin microbiota regulation of barrier integrity and repair

Elizabeth Grice (UPenn, USA)

Short communications

13.45-14.00

Antimicrobial late cornified envelope (LCE) proteins: the psoriasis risk factor LCE3B/C-del affects microbiota composition

Hanna Niehues (Nijmegen, The Netherlands)

14.00-14.15

Segregation of filaggrin into small extracellular vesicles secreted by keratinocytes as a barrier homeostatic mechanism hijacked by Staphylococcus aureus

Danuta Gutowska-Owsiak (Gdansk, Poland)

14.15-15.15

Poster viewing + coffee/tea

Session 4: Epidermal function in skin diseases

Short communications

15.15-15.30

Untangling the complex cytokine milieu in psoriasis and atopic dermatitis through organotypic epidermal models

Luca Meesters (Nijmegen, The Netherlands)

15.30-15.45

Aryl hydrocarbon receptor ligand leflunomide exerts triple action to dampen the inflammatory skin disease atopic dermatitis

Felicitas Pardow (Nijmegen, The Netherlands)

15.45-16.00

Experimental approaches for testing the pathogenicity of variants of uncertain signification to reduce diagnosis deadlocks in ichthyoses

Nuria Pell-Vidal (Paris, France)

16.00-16.15

CD44 functions as a novel interacting partner of Aquaporin 5 in keratinocytes

Laura Ramos Del Caño (London, UK)

16.15-16.30

Meeting closure, announcement of presentation prizes, departure for drinks

Ellen van den Bogaard + Sara Brown