PROGRAM

[ABSTRACT 425]

GRPR is an effective target for melanoma

J Raymond, M Pouteaux, V Petit, Z Aktary, L Larue and V Delmas Team Larue – INSERM U1021 – CNRS UMR3347, Institut Curie, Orsay, France

[ABSTRACT 430]

A non-transcriptional role of the oncoprotein YAP in cutaneous squamous cell carcinoma

J Bojko and G Walko Department of Life Sciences, University of Bath, Bath, United Kingdom

[ABSTRACT 431]

PVT1 is overexpressed in cutaneous squamous cell carcinoma and acts as an oncogenic long non-coding RNA

C Li,² C Sun,² K Das Mahapatra,¹ J Lapins,³ V Kahari,⁴ E Sonkoly² and A Pivarcsi^{2 1} Karolinska Institutet, Stockholm, Sweden, ² Uppsala University, Uppsala, Sweden, ³ Karolinska University Hospital, Stockholm, Sweden and ⁴ Turku University Hospital and University of Turku, Turku, Finland

[ABSTRACT 437]

Single-cell RNA sequencing reveals specific T cell and fibroblast populations that can distinguish early mycosis fungoides from parapsoriasis and atopic dermatitis lesions

N Alkon,² M Drach,² L Shaw,² U Mann,² J Valencak,² W Weninger,² J Griss,² M Farlik,² C Jonak² and PM Brunner¹,^{2 1} Dermatology, Icahn School of Medicine at Mount Sinai, New York, NY and ² Medical University of Vienna, Vienna, Austria

[ABSTRACT 266]

The exosome-associated miR-146a modulates cellular senescence and senescence-associated secretory phenotype (SASP) in Head and Neck SCC (HNSCC)

BL Hill, A Calder, J Flemming, Y Guo, S Gilmore, A Linnenbach, A South, L Harshyne, A Luginbuhl and MG Mahoney Thomas Jefferson University, Philadelphia, PA

[ABSTRACT 438]

CD271 modulates cutaneous squamous cell carcinoma growth and invasion in patient-derived spheroids and zebrafish avatar

M Quadri,¹ L Reggiani Bonetti,² R Panini,² N Tiso,³ M Morasso,⁴ R Lotti,¹ A Marconi,¹ C Pincelli¹ and E Palazzo^1 1 ChiMoMo, University of Modena and Reggio Emilia, Modena, Italy, ² Pathology, UNIMORE, Modena, Italy, ³ Biology, UNIPD, Padova, Italy and ⁴ Lab. Skin Biology, NIH, Bethesda, MD

[ABSTRACT 427]

Inhibiting insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1) reduces tumor development in the basal cell carcinoma mouse model PTCH+/-

C Harris,¹ M Hajahmed,¹ O Odubanjo,¹ C Yedjou,⁴ V Spiegelman,³ J Chamcheu,² T Roy,² S Boetang,² R Chamcheu² and F Noubissi^1 1 Biology, Jackson State University, Jackson, MS, ² University of Louisiana at Monroe, Monroe, LA, ³ Pennsylvania State University, Hershey Medical Center, Hershey, PA, Hershey, PA and ⁴ Department of Biology, Florida A&M University, Tallahassee, FL

[ABSTRACT 432]

Integrated multi-omics reveals cellular and molecular interactions governing the invasive niche of basal cell carcinoma

L Yerly,¹ C Pich Bavastro,¹ J Di Domizio,¹ T Wyss,² S Tissot,³ M Cangkrama,⁴ M Gilliet,¹ S Werner⁴ and F Kuonen^{1 1} Department of Dermatology and Venereology, Lausanne University Hospital Center, Lausanne, Switzerland, ² Swiss Institute of Bioinformatics, Lausanne, Switzerland, 3 Department of Oncology, Lausanne University Hospital Center, Lausanne, Switzerland and ⁴ Department of Biology, Institute of Molecular Health Sciences, ETH Zurich, Zürich, Switzerland

[ABSTRACT 428]

A multi-scale spatial atlas of human skin across anatomical sites and cutaneous malignancy reveals novel cell states and repurposing of fibroblast subpopulations in skin cancer stroma

C Ganier,¹ X Du-Harpur,¹ GE Herrera,² J Gabriel,¹ N Harun,¹ F Watt¹ and M Lynch^1 1 Centre for Gene Therapy and Regenerative Medicine, King’s College London, London, United Kingdom and ² Centre for Developmental Neurobiology, King’s College London, London, United Kingdom