PROGRAM

[LB039]

Palmoplantar keratoderma as a clinical feature of pathogenic variants in the filaggrin gene

Julia Clabbers¹, Marieke Bolling², Charlotte Burms¹, Maaike Vreeburg³, Henny Lemmink⁴, Peter van den Akker⁴, Peter Steijlen¹, Michel van Geel¹, Antoni Gostyński^{1 1}Department of Dermatology, Maastricht University Medical Centre+, Maastricht, The Netherlands, ²Department of Dermatology, University Medical Centre Groningen, Groningen, The Netherlands, ³Department of Clinical Genetics, Maastricht University Medical Centre+, Maastricht, The Netherlands, ⁴Department of Genetics, University Medical Centre Groningen, Groningen, The Netherlands

[LB025]

Neurotrophin Signaling in Epithelial to Mesenchymal Transition as a Potential Target in Melanoma Therapy

Laura Bertoni¹, Marika Quadri³, Paola Sena¹, Giulia Orlandi¹, Elisabetta Palazzo³, Roberta Lotti³, Francesca Farnetani², Alessandra Marconi^{3 1}Morphological Sciences Sections, Dept of Surgical, Medical, Dental and Morphological Sciences, UNIMORE, Modena, Italy, ²Dermatology Unit, Dept of Surgical, Medical, Dental and Morphological Sciences, University of Modena and Reggio Emilia, Modena, Italy, ³DermoLab, Dept of Surgical, Medical, Dental and Morphological Sciences, UNIMORE, Modena, Italy

[LB017]

Uncoupling Desmosomal Cadherin Adhesion Activates Stem Cells in the Quiescent Hair Follicle

William V.J. Hariton,^1,2,3  Katja Schulze,^3,4,5  Roman Schwob,^3,4  Andrew M. Overmiller,⁶ My G. Mahoney,⁶  Luca Borradori,^1,3 Beyza S. Sayar,^1,2,3 Arnaud Galichet,^1,3,4 Eliane J. Müller^{1,2,3,4 1}Department of Dermatology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland, ² Department for BioMedical Research, Molecular Dermatology and Stem Cell Research, University of Bern, Bern, Switzerland, ³DermFocus, Vetsuisse Faculty, University of Bern, Bern, Switzerland, ⁴ Institute of Animal Pathology, Vetsuisse Faculty, University of Bern, Bern, Switzerland, ⁵Genentech Inc., Roche, San Francisco, CY, USA, ⁶Department of Dermatology and Cutaneous Biology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA

[LB003]

CK1⍺ Inhibition in Keratinocytes of Mc1r Defective Mice Prevents Ultraviolate-induced Skin Damage

Chung-Hsing Chang^1,2,3, Wei-Ping Huang^2,3, Ho-Jen Chen³, Chien-Hung Chen^{3 1}Doctoral Degree Program in Translational Medicine, Tzu Chi University and Academia Sinica, Hualien, Taiwan ²Institute of Medical Sciences, Tzu Chi University, Hualien, Taiwan ³Skin Institute, Hualien Tzu Chi Hospital, Hualien, Taiwan

[LB009]

IL-4/IL-13 inhibitors for atopic dermatitis induce psoriatic rash transcriptionally close to pustular psoriasis 

Chloé Grolleau^1,2, Andreea Calugareanu^2,3, Sarah Demouche^1,2, Audrey Nosbaum³, Delphine Staumont-Sallé⁴, Hélène Aubert⁵, Antonio Alberdi⁶, Alexandre How-Kit⁷, Jean-David Bouaziz^1,2, Hélène Le-Buanec^{2 1}Dermatology department, Hôpital Saint Louis, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris ²Université de Paris, INSERM U976 – HIPI Unit, Institut de Recherche Saint-Louis, Paris, France ³Dermatology department, CHU Lyon Centre, Hospices civils de Lyon (HCL), France ⁴Dermatology department, CHU Lille, U1286 Inserm INFINITE, Univ. Lille, Lille, France ⁵Dermatology department, Nantes University Hospital, Nantes, France ⁶Plateforme Technologique IRSL, UFR Médecine, Université de Paris, Hôpital Saint-Louis, Paris, France. ⁷Laboratory of Genomics, Foundation Jean Dausset-CEPH, Paris, France

[LB032]

Driver gene combinations dictate cutaneous squamous cell carcinoma disease continuum progression

Peter Bailey¹, Rachel Ridgway², Christina Schoenherr², Mairi Treanor-Taylor², Alexander J. Stratigos³, Charlotte M. Proby⁴, Catherine A. Harwood⁵, Owen J. Sansom², Irene M. Leigh⁵ and Gareth J. Inman^{2 1}Institute of Cancer Sciences, University of Glasgow, United Kingdom ²Cancer Research UK Beatson Institute, Glasgow, United Kingdom ³1st Department of Dermatology – Venereology, Andreas Sygros Hospital, National and Kapodistrian University of Athens, School of Medicine, Greece ⁴Jacqui Wood Cancer Centre, University of Dundee, United Kingdom ⁵Centre for Cell Biology and Cutaneous Research, Blizzard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, United Kingdom

[LB042]

Targeting Melanoma Plasticity to Improve both Targeted and Immune Therapy

Satoru Sugihara¹, Jacinta Simmons², Yimeng Guan¹, Gency Gunasingh¹, Jordan Kumar¹, Rituparna Bhatt¹, Riccardo Dolcetti¹, Glen Boyle², Loredana Spoerri¹, Nikolas K. Haass^{1 1}The University of Queensland Diamantina Institute, The University of Queensland, Brisbane, QLD, Australia ²QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia

[LB033]

Clinical trial using dermal open flow microperfusion (dOFM) elucidates mechanisms of dupilumab (Dupixent) on downstream signal pathways and indicates differences in local and systemic effects

Barbara Ehall¹, Anita Eberl², Manfred Bodenlenz², Katrin Tiffner², Thomas Birngruber², Eva Svehlikova¹, Thomas Pieber^{1 1}Division for Endocrinology and Diabetology, Department for Internal Medicine, Medical University of Graz, Graz, Austria;  ²HEALTH- Institute of Biomedicine and Health Science, Joanneum Research, Graz, Austria

Tyrosine-derivated-peptide increases hair follicles melanogenesis via a MITF, CREB, and TYRP1 dependent pathway

Philippe Mondon, Caroline Ringenbach, Thomas Ondet, Olivier Peschard,  Emmanuel Doridot, Richard Leroux SEDERMA, Le Perray-en-Yvelines, France