PROGRAM

[ABSTRACT 315]

PPAR-γ promotes cystine uptake to prevent unchecked lipid ROS and cell death in Th9 cells

C Bazzini, NL Bertschi, F Luther, O Steck, N Begré and C Schlapbach Dermatology, Inselspital, Bern University Hospital, Bern, Switzerland

[ABSTRACT 003]

Interleukin (IL)-26 drives pathogenic IL-17A responses through a TH17-keratinocyte crosstalk

A Fries,¹ F Saidoune,¹ F Kuonen,¹ C Conrad,¹ I Dupanloup,² A Guerra de Souza,² N Fournier,² R Gottardo,³ J Di Domizio¹ and M Gilliet^{1 1} Dermatology, University Hospital Lausanne CHUV, Lausanne, Switzerland, ² Translational Data Science, Swiss Institute of Bioinformatics, Lausanne, Switzerland and ³ Biomedical Data Sciences Center, CHUV, UNIL, and Swiss Institute of Bioinformatics, Lausanne, Switzerland

[ABSTRACT 259]

KLF4 variants: a novel cause of palmoplantar keratoderma

K Malovitski,^1,2 O Sarig,¹ S Assaf,^1,2 J Mohamad,^1,2 S Bergson,^1,2 A Peled,^1,2 M Eskin-Schwartz,^3,4 A Gat,⁵ M Pavlovsky^1,2 and E Sprecher^{1,2 1} Division of Dermatology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel, ² Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel, ³ Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel, ⁴ Genetic Institute, Soroka University Medical Center, Beer Sheva, Israel and ⁵ Insititute of Pathology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel

[ABSTRACT 426]

STAT3/5 locus gain is a disease marker and therapeutic target in leukemic/cutaneous T cell lymphoma

S Dey,^1,3 H Sorger,^2,3 P Vieyra-Garcia,¹ A Teufelberger,¹ M Herling,⁴ E Heitzer,⁵ PT Gunning,⁶ L Kenner,³ R Moriggl² and P Wolf^{1 1} Department of Dermatology, Medical University of Graz, Graz, Austria, ² University of Veterinary Medicine, Vienna, Austria, ³ Medical University of Vienna, Vienna, Austria, ⁴ Department of Medicine I, CECAD and CMMC, Cologne University, Cologne, Germany, ⁵ Institute of Human Genetics, Medical University of Graz, Graz, Austria and ⁶ University of Toronto Mississauga, Mississauga, ON, Canada

[ABSTRACT 424]

Perivascular niches dictate developmental cellular hierarchies during melanoma growth

P Karras,¹ I Bordeu,² J Pozniak,¹ A Nowosad,¹ C Pazzi,¹ N Van Raemdonck,¹ E Landeloos,¹ C Blanpain,³ F Rambow¹ and J Marine^{1 1} VIB Center for Cancer Biology, Leuven, Belgium, ² Department of Applied Mathematics and Theoretical Physics, Centre for Mathematical Sciences, University of Cambridge, Cambridge, United Kingdom and ³ Free University of Brussels, Brussels, Belgium

[ABSTRACT 590]

Schwann cells – an unexpected key player in keloid formation

M Direder,^1,2 T Weiss,³ D Copic,^1,2 V Vorstandlechner,³ K Klas,^1,2 M Laggner,^1,2 M Wielscher,⁴ D Bormann,^1,2 HJ Ankersmit^1,2 and M Mildner^{4 1} Thoracic Surgery, Medical University of Vienna, Vienna, Austria, ² Aposcience AG, Vienna, Austria, ³ Plastic, Reconstructive and Aesthetic Surgery, Medical University of Vienna, Vienna, Austria and ⁴ Dermatology, Medical University of Vienna, Vienna, Austria

[ABSTRACT 073]

Risk of severe COVID-19 outcomes associated with immune-mediated inflammatory diseases and immune modifying therapies: a nationwide cohort study in the OpenSAFELY platform

S Langan,¹ C Smith² and T Collaborative^{3 1} London School of Hygiene and Tropical Medicine, London, United Kingdom, ² King’s College, London, United Kingdom and ³ University of Oxford, Oxford, United Kingdom