Professor Grieshaber-Bouyer studied medicine and business administration. He received his clinical training in medicine, rheumatology, and immunology at the Universities of Heidelberg and Zurich, at Duke University School of Medicine, and at Harvard Medical School. His immunological research focuses on neutrophils, inflammatory arthritis, and bioinformatics. After postdoctoral training with the Boston-based ImmGen Consortium, he then established a DFG-funded research group at Heidelberg University as clinician scientist, focusing on neutrophil heterogeneity in rheumatic disease.

He was then appointed Professor of Clinical Systems Immunology at FAU Erlangen-Nürnberg. In his clinical role he heads the clinical trial unit and focuses on the interdisciplinary care of patients with rheumatic and immune-mediated diseases, particularly in the context of emerging immunotherapies such as T cell engagers and CAR T cell therapies. His research group investigates the mechanisms driving immune cell heterogeneity in tissues and inflammatory conditions and develops new bioinformatics analysis tools for high dimensional data.