ESDR 2021 Keynote Lecture: Immunity
Title: Dynamic Plasticity and Resistance of Keratocarcinomas
Date: Thursday 23 September 2021, 16.00-16.30
Dr. Oro is the Eugene and Gloria Bauer Professor of Dermatology at Stanford University, Program in Epithelial Biology, Associate Director of the Center for Definitive and Curative Medicine, and co-director of the Child Health Research Institute. Dr. Oro uses the skin to address mechanistic question in regenerative medicine, cancer, and autoimmunity. He has a longstanding interest in the mechanisms of hedgehog signaling in the pathogenesis of the most common human tumor, basal cell carcinoma of the skin, recently focusing on tumor evolution and novel resistance-associated signaling pathways. He has identified several novel cancer pathways and focuses on developing inhibitors for treating resistant cancer. His interest in skin development and early ectodermal differentiation has led to the development of in vitro human skin differentiation protocols and genome editing tools to produce clinical scale, corrected, autologous human skin from patient-specific induced pluripotent cells.